Analytical Data
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基因名
ST2/IL1RL1
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简介
The ST2/IL1RL1 protein serves as a receptor for IL-33 and plays a crucial role in immunity and response to environmental stress through IL1RAP.It recruits MYD88, IRAK1/4 and TRAF6 upon stimulation, leading to MAPK phosphorylation.ST2/IL1RL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ST2/IL1RL1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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生物活性
Measured in a cell proliferation assay using A549 cells. The ED50 for this effect is 34.04 ng/mL in the presence of 20 ng/mL recombinant mouse IL-33, corresponding to a specific activity is 2.51×105 units/mg. Measured in a cell proliferation assay using A549 cells. The ED50 for this effect is 34.04 ng/mL in the presence of 20 ng/mL recombinant mouse IL-33, corresponding to a specific activity is 2.51×105 units/mg.
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别名
Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Il1rl1; Ly84; St2; Ste2
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P14719-2
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表达区间
S27-A337
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氨基酸序列
SKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPSKECPSHIA
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蛋白长度
Partial
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ST2, also known as IL1RL1, is a receptor for interleukin-33 (IL-33), a member of the IL-1 cytokine family. This protein is crucial for mediating immune responses, particularly in the context of inflammation and allergic diseases. Elevated levels of ST2 and IL-33 have been associated with various pathological conditions, including asthma, cardiovascular diseases, and fibrosis. Understanding the biology of ST2 can provide insights into its role in immune regulation and disease pathogenesis. Recent studies have focused on the development of recombinant ST2 proteins to further explore its functions and potential therapeutic applications. These recombinant proteins can be utilized in assays to investigate the receptor's signaling pathways, interactions with other cytokines, and its role in modulating immune responses. Moreover, recombinant ST2 has emerged as a candidate for biomarker development, given its association with disease severity in asthma and heart failure. Research on this protein is paving the way for novel therapeutic strategies aimed at targeting the ST2/IL-33 axis, with the potential to alleviate inflammatory diseases and improve patient outcomes.
