Analytical Data
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基因名
IL-22RA2
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简介
IL-22BP/IL-22RA2 proteins (especially isoform 2) act as IL22 receptors and antagonists, inhibiting IL22 activity by preventing its interaction with functional IL-22R complexes in vitro. This regulatory effect suggests its potential in modulating inflammatory responses. IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived IL-22BP/IL-22RA2 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
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别名
Interleukin-22 receptor subunit alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; ZcytoR16
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种属
Human
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表达系统
HEK293
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标签
C-hFc;C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q969J5
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表达区间
T22-P231
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蛋白长度
Partial
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分子量
80-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-22 receptor subunit alpha 2 (IL-22RA2) is a decoy receptor that plays a critical role in regulating the immune response, particularly in inflammation and tissue regeneration. Unlike its counterpart IL-22RA1, which is part of the signaling complex for the pro-inflammatory cytokine IL-22, IL-22RA2 functions by binding to IL-22 and inhibiting its activity, thus preventing excessive inflammatory responses. This mechanism is particularly significant in various diseases, including autoimmune disorders, infections, and certain types of cancer. The study of IL-22RA2 as a recombinant protein has gained attention due to its potential therapeutic implications. Researchers are exploring its role in modulating the immune response to restore balance in inflammatory conditions while also investigating its utility as a biomarker for diseases characterized by dysregulated IL-22 signaling. Recombinant IL-22RA2 could serve as a valuable tool for understanding the complexities of cytokine interactions and the therapeutic modulation of immune responses. By elucidating its structure, function, and interactions with other cytokines, this research may pave the way for new treatment strategies targeting IL-22-related pathways, offering hope for improved management of chronic inflammatory diseases.
