Analytical Data
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基因名
FOLR1
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简介
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, His) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR
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种属
Canine
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_851993.1
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表达区间
R25-M228
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氨基酸序列
RTELLNVCMDAKHHKEKPSPEDGLHKQCSPWKKNSCCFANTSREAHKDISYLYRFNWNHCGSMTPACKKHFIQDTCLYECSPNLGPWIQEVNQSWRKERILHVPLCKEDCEQWWQDCRTSYTCKSNWHKGWNWTSGYNQCPEGAACHPFHFYFPTSAALCSEIWSHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYARAM
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蛋白长度
Partial
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分子量
27-40 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOLR1, or folate receptor alpha, is a glycoprotein that plays a crucial role in folate absorption, which is essential for DNA synthesis and cell division. It is highly expressed in various tissues, particularly in the placenta and certain tumors, making it a significant target for cancer therapies. The overexpression of FOLR1 in tumor cells, combined with its limited expression in normal tissues, provides a strategic opportunity for targeted drug delivery and imaging. Research on the recombinant FOLR1 protein has gained momentum due to its potential applications in developing novel therapeutic agents and diagnostic tools. Scientists are exploring the development of antibody-drug conjugates (ADCs) that utilize FOLR1 as a targeting moiety, allowing for selective delivery of cytotoxic drugs to cancer cells while minimizing systemic toxicity. Furthermore, studies on the structure and function of recombinant FOLR1 facilitate insights into its role in folate metabolism and its implications in diseases related to folate deficiency. Understanding the interactions between FOLR1 and its ligands can lead to the identification of biomarkers for tumor diagnosis and prognosis. Thus, the research surrounding recombinant FOLR1 is pivotal, as it not only enhances our comprehension of folate biology but also paves the way for innovative therapeutic strategies that could significantly improve cancer treatment outcomes.
