Analytical Data
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Gene name
CD1B
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简介
CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D1-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~40-50 & 12 KDa, respectively.
- Application
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Alternative Names
Antigen-presenting glycoprotein CD1d1; Cd1d1; Beta-2-microglobulin
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11609 (Q22-W297)&P01887
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Expression Region
P11609 (Q22-W297)&P01887 (I21-M119)
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Molecular Weight
40-50 & 12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD1B is a member of the CD1 family of glycoproteins that play a crucial role in the immune system by presenting lipid antigens to T cells. Unlike classical MHC (Major Histocompatibility Complex) molecules, CD1B is specialized in the presentation of non-peptide antigens, including lipids and glycolipids derived from various pathogens. This ability is particularly important for the immune response against certain bacteria, such as Mycobacterium tuberculosis, which has unique lipid components that evade detection by conventional T cells. Research into recombinant CD1B proteins has gained momentum due to their potential applications in vaccine development and immunotherapy, particularly for diseases where conventional peptide-based vaccines are less effective. By studying CD1B and its interactions with T cell receptors, researchers aim to understand its unique antigen-presentation mechanisms and leverage this knowledge to develop innovative strategies for enhancing immune responses against specific pathogens. Furthermore, recombinant CD1B proteins can serve as valuable tools for elucidating the role of lipid antigens in immune responses, ultimately contributing to the design of targeted immunotherapies for infectious diseases and cancer. These insights may also extend to the understanding of autoimmune diseases, where lipid dysregulation may play a role. The ongoing exploration of CD1B emphasizes its importance in the intersection of lipid biology and immunology, marking it as a significant focus area for future research and therapeutic development.
