Analytical Data
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基因名
CD1B
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简介
CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived CD1D protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
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别名
Antigen-presenting glycoprotein CD1d; CD1D; R3G1
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11609
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表达区间
M1-G305
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蛋白长度
Extracellular Domain
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分子量
60.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD1B is a member of the CD1 family of glycoproteins that play a crucial role in the immune system by presenting lipid antigens to T cells. Unlike classical MHC (Major Histocompatibility Complex) molecules, CD1B is specialized in the presentation of non-peptide antigens, including lipids and glycolipids derived from various pathogens. This ability is particularly important for the immune response against certain bacteria, such as Mycobacterium tuberculosis, which has unique lipid components that evade detection by conventional T cells. Research into recombinant CD1B proteins has gained momentum due to their potential applications in vaccine development and immunotherapy, particularly for diseases where conventional peptide-based vaccines are less effective. By studying CD1B and its interactions with T cell receptors, researchers aim to understand its unique antigen-presentation mechanisms and leverage this knowledge to develop innovative strategies for enhancing immune responses against specific pathogens. Furthermore, recombinant CD1B proteins can serve as valuable tools for elucidating the role of lipid antigens in immune responses, ultimately contributing to the design of targeted immunotherapies for infectious diseases and cancer. These insights may also extend to the understanding of autoimmune diseases, where lipid dysregulation may play a role. The ongoing exploration of CD1B emphasizes its importance in the intersection of lipid biology and immunology, marking it as a significant focus area for future research and therapeutic development.
