Analytical Data
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基因名
L1CAM
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简介
The L1CAM protein is a neural cell adhesion molecule that plays a critical role in cell adhesion dynamics and initiation of tyrosine kinase receptor transmembrane signaling. Its importance spans brain development, affecting processes such as neuronal migration, axonal growth, fasciculations, and synaptogenesis. L1CAM Protein, Human (HEK293, His) is the recombinant human-derived L1CAM protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Neural cell adhesion molecule L1; NCAM-L1; CD171; L1CAM; CAML1; MIC5
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32004
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表达区间
I20-E1120
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蛋白长度
Extracellular Domain
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分子量
160-200 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
L1CAM (L1 Cell Adhesion Molecule) is a critical protein involved in various biological processes, including cell adhesion, neuronal development, and axon guidance. Its dysregulation is implicated in several neurological disorders and cancers, making it a significant focus of research. The recombinant expression of L1CAM allows for detailed studies of its structure, function, and interactions, overcoming the limitations posed by natural sources. By using techniques such as recombinant DNA technology, researchers can produce L1CAM in various host systems, enabling investigations into its biochemical properties and role in cell signaling. Additionally, recombinant L1CAM can be utilized in therapeutic applications, such as targeted drug delivery and immunotherapy, by leveraging its adhesion properties to enhance cellular interactions and targeting specificity. Understanding the functionality of L1CAM at the molecular level can provide insights into its potential as a biomarker or therapeutic target, thereby contributing to the development of innovative strategies for treating related diseases.
