Analytical Data
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Gene name
CD96
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简介
CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (HEK293, mFc) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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Alternative Names
CD96 molecule; CD96; DKFZp667E2122; TACTILE
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40200-2
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Expression Region
V22-M503
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Protein Length
Partial
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Molecular Weight
120-160 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD96, also known as Tactile or DNAM-1, is an immune receptor that plays a significant role in the regulation of immune responses, particularly in the context of tumor immunology and viral infections. Identified as a member of the immunoglobulin superfamily, CD96 is expressed on various immune cells, including T cells, natural killer (NK) cells, and dendritic cells. It interacts with its ligands, such as PVR (Poliovirus receptor) and Nectin-2, facilitating immune cell adhesion and activation. Research has shown that CD96 can have both positive and negative impacts on immune responses, making it a target of interest for cancer immunotherapy. In tumor microenvironments, CD96 expression can be associated with immune evasion strategies employed by cancer cells. Consequently, the production of recombinant CD96 protein has become a focal point for studying its biochemical properties, signaling pathways, and potential as a therapeutic target. Understanding the functional role of CD96 through recombinant protein studies can provide insights into developing novel immune checkpoint inhibitors or enhancing existing immunotherapies, ultimately aiming to improve patient outcomes in oncology and infectious disease.
