Analytical Data
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基因名
MAG/Siglec-4a
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简介
MAG/Siglec-4a is an adhesion molecule that binds to neuronal gangliosides, RTN4R, and RTN4RL2, promoting myelination interactions. Although not important for initial myelination, it may maintain axonal myelination and protect motor neurons, especially after injury, through interactions with RTN4R and RTN4RL2. MAG/Siglec-4a Protein, Human (HEK293, Fc) is the recombinant human-derived MAG/Siglec-4a protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Myelin-Associated Glycoprotein; Siglec-4a; MAG; GMA
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20916-1
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表达区间
G20-P516
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蛋白长度
Extracellular Domain
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分子量
113 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Magnetic (MAG) and sialic acid-binding immunoglobulin-like lectin 4A (Siglec-4a) are essential components in understanding the immune system and neurological health. MAG, a member of the myelin-associated glycoprotein family, plays a critical role in the formation and maintenance of the myelin sheath, which is essential for proper neural signal transmission. It has been implicated in various neurological disorders, including multiple sclerosis, where its interaction with axons can affect nerve protection and regeneration. On the other hand, Siglec-4a, known for its capacity to bind sialic acids, is predominantly expressed in immune cells and modulates immune responses via its inhibitory signaling pathways. Research has shown that the interaction between MAG and Siglec-4a may influence neuroinflammation and immune regulation in the central nervous system. Investigating the recombinant proteins of MAG and Siglec-4a offers insights into their functional roles and potential therapeutic applications. Understanding these proteins' interactions can pave the way for novel treatment strategies targeting neurological diseases and immune-related conditions. This research highlights the significance of the MAG/Siglec-4a axis in modulating both neuronal and immune responses, underscoring their potential as biomarkers and therapeutic targets in clinical settings.
