Analytical Data
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Gene name
ICOS
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简介
ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus macaque (HEK293,Fc) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
H9Z062
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Expression Region
G20-K140
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Protein Length
Partial
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Molecular Weight
50-60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ICOS (Inducible T-cell COStimulator) is a member of the CD28 family of costimulatory molecules pivotal for T-cell activation and immune response regulation. Its role in mediating signals that promote T-cell proliferation, differentiation, and survival has made it a significant focus in immunological research. The ICOS pathway has been implicated in various diseases, particularly autoimmune disorders and cancers, as dysregulation of ICOS signaling can lead to excessive immune responses or inadequate tumor immunity. Consequently, researchers have been exploring ICOS as a therapeutic target. The study of recombinant ICOS proteins involves understanding their structure, function, and interactions with other immune molecules, enabling insights into their pivotal role in immune modulation. Additionally, recombinant ICOS proteins can be used in preclinical models to assess their potential as predictive biomarkers or therapeutic agents. The development of ICOS-targeting therapies, such as monoclonal antibodies or agonists, holds promise for enhancing immune responses in cancer immunotherapy or restoring balance in autoimmune diseases. Therefore, investigating ICOS recombinant proteins is crucial for developing innovative immunotherapeutic strategies that leverage the body's immune system to achieve more effective disease management.
