Analytical Data
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Gene name
CD74
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简介
The CD74 protein is significantly expressed in the thymus and lymph nodes, suggesting that it plays a key role in regulating immune system function. Its presence in the thymus, a key site for T cell development, underscores its important role in overseeing key cellular processes required for immune maturation. CD74 Protein, Mouse (160a.a, HEK293, His) is the recombinant mouse-derived CD74 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
H-2 class II histocompatibility antigen gamma chain; CD74; CLIP; DHLAG
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04441-2
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Expression Region
Q56-L215
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Protein Length
Extracellular Domain
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Molecular Weight
25-30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD74, also known as the invariant chain, is a membrane protein that plays a critical role in the immune response by facilitating the presentation of antigens to T cells. It serves as a chaperone for Major Histocompatibility Complex (MHC) class II molecules during their synthesis and transport within antigen-presenting cells. In recent years, research has highlighted the multifaceted functions of CD74 beyond its traditional role in immune signaling, including its involvement in cell proliferation, survival, and migration in various pathologies such as cancer and autoimmune diseases. Given its increased expression in several tumors, CD74 has garnered attention as a potential therapeutic target and a biomarker for disease progression. The production of recombinant CD74 proteins allows for detailed studies into its structural and functional properties, as well as its interactions with various ligands and receptors. This biochemical characterization is essential for understanding its role in immune regulation and pathology, thereby paving the way for the development of novel immunotherapeutic strategies. The ongoing exploration of CD74 in both normal physiology and disease states underscores its importance in immunology and highlights its potential as a target for innovative therapeutic interventions.
