Analytical Data
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Gene name
CD105/Endoglin
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简介
CD105/endoglin is a vascular endothelial glycoprotein that plays an important regulatory role in angiogenesis and maintains the structure of the adult vasculature. It controls vascular endothelial cell migration and contributes to extraembryonic angiogenesis and embryonic heart development. CD105/Endoglin Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD105/Endoglin protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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Alternative Names
CD105; Endoglin; ENG; ORW; ORW1; END; HHT1
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17813-1
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Expression Region
E26-G586
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Protein Length
Extracellular Domain
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Molecular Weight
70-82 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD105, also known as endoglin, is a type I transmembrane protein and a co-receptor for transforming growth factor-beta (TGF-β), playing a crucial role in angiogenesis and vascular remodeling. It is primarily expressed on the surface of endothelial cells and is implicated in various physiological and pathological processes, including wound healing, tumor progression, and inflammatory responses. The significance of CD105 in these processes has led researchers to investigate its potential as a therapeutic target and a biomarker for several diseases, such as cancer and vascular disorders. The recombinant protein of CD105 is utilized in various research applications to better understand its biological functions and interactions within cellular pathways. Studies have shown that modulation of CD105 expression affects endothelial cell proliferation, migration, and tube formation, highlighting its importance in angiogenesis. Furthermore, CD105 has been identified as a promising target for targeted drug delivery and immunotherapy, given its restricted expression on activated endothelial cells in tumors. As such, ongoing research focuses on characterizing CD105/Endoglin recombinant proteins for their potential use in diagnostic and therapeutic strategies, paving the way for advancements in precision medicine and targeted cancer therapies. Understanding the molecular mechanisms of CD105 can provide insights into novel therapeutic approaches, enhancing the effectiveness of treatments for various diseases characterized by aberrant angiogenesis and vascular dysfunction.
