Analytical Data
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Gene name
LRP-1 Cluster II
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简介
LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster II Protein, Human (HEK293, His) is the recombinant human-derived LRP-1 Cluster II protein, expressed by HEK293 , with C-10*His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant LRP-1 Cluster II Protein is immobilized at 50 ng/mL (100 μL/well) can bind Recombinant Human LRPAP (HY-P76478). The ED50 for this effect is 2.302 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant LRP-1 Cluster II Protein is immobilized at 50 ng/mL (100 μL/well) can bind Recombinant Human LRPAP (HY-P76478). The ED50 for this effect is 2.302 ng/mL.
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Alternative Names
A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5
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Species
Human
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q07954
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Expression Region
R786-L1165
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AA Sequence
RPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKL
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Protein Length
Partial
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Molecular Weight
65-80 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP-1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional receptor that plays a critical role in various physiological processes, including lipid metabolism, cell signaling, and clearance of extracellular matrix components. Cluster II refers to a specific domain or segment of LRP-1 that has garnered attention due to its involvement in various pathophysiological conditions such as Alzheimer's disease, cancer, and cardiovascular disorders. Research on LRP-1 Cluster II recombinant proteins is vital for understanding its structural and functional characteristics, as these proteins can provide insights into the receptor's mechanisms of action. Furthermore, the study of recombinant LRP-1 Cluster II proteins may reveal potential therapeutic targets for diseases linked to LRP-1 dysregulation. By elucidating how the receptor interacts with its ligands and mediates cellular responses, researchers aim to develop novel strategies for disease prevention and treatment. The growing interest in harnessing recombinant technology to produce LRP-1 Cluster II proteins underscores the importance of this area of research in enhancing our understanding of receptor biology and its implications for human health.
