Analytical Data
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基因名
CD28
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简介
CD28 Protein, a crucial regulator of T-cell activation, promotes cell proliferation, cytokine production, and T-cell survival. It enhances IL4 and IL10 production when combined with TCR/CD3 ligation and CD40L costimulation. CD28 Protein exists as a disulfide-linked homodimer and interacts with DUSP14, CD80/B7-1, CD86/B7-2/B70, and GRB2 (By similarity). CD28 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD28 protein, expressed by HEK293, with C-hFc labeled tag.
- Application
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别名
T-cell-specific surface glycoprotein CD28; CD28
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31041
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表达区间
N20-K149
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分子量
55-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD28 is a vital co-stimulatory molecule expressed on T cells, playing a crucial role in their activation and function. It binds to its ligands, CD80 and CD86, present on antigen-presenting cells, providing essential signals for T cell proliferation, survival, and differentiation. Research into CD28 has advanced significantly, particularly concerning its role in immune responses, T cell activation pathways, and potential therapeutic applications in immunotherapy. Recombinant CD28 proteins have emerged as valuable tools for studying T cell biology, facilitating the understanding of T cell receptor signaling and co-stimulation. Through the production of recombinant CD28, researchers can investigate its interactions in a controlled environment, providing insights into its structural and functional properties. Moreover, understanding CD28's mechanisms may lead to novel strategies for enhancing anti-tumor immunity or regulating autoimmune diseases. The potential for using recombinant CD28 in combination therapies, alongside checkpoint inhibitors or other immunomodulatory agents, highlights its relevance in improving therapeutic outcomes in various diseases. Overall, the study of CD28 and its recombinant forms is essential for advancing our knowledge about immune regulation and developing next-generation immunotherapies.
