Analytical Data
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Gene name
CD46
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简介
CD46 protein is an important cofactor for complement factor I, a serine protease that protects autologous cells by cleaving deposited C3b and C4b. In addition to complement regulation, CD46 is involved in sperm-oocyte fusion during fertilization. CD46 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD46 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
TLX; CD46; MCP; MIC10; AHUS2; TRA2.10
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5WCS2
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Expression Region
C35-D329
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Protein Length
Partial
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Molecular Weight
50-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD46, also known as membrane cofactor protein (MCP), is a crucial regulator of the immune system, primarily recognized for its role in protecting host cells from complement-mediated lysis. It serves as a cofactor for Factor I in cleaving C3b and C4b, thereby modulating the complement pathway and preventing excessive inflammation. Research into CD46 has gained momentum due to its involvement in various pathological conditions, including autoimmunity, infectious diseases, and cancer. The role of CD46 in viral entry, particularly for viruses like the measles and adenoviruses, highlights its significance beyond complement regulation. Recombinant CD46 proteins have emerged as valuable tools for scientific investigation, enabling researchers to study its molecular interactions, expression patterns, and functional implications in health and disease. By generating and characterizing CD46 recombinant proteins, scientists aim to elucidate its mechanisms and explore potential therapeutic interventions, such as enhancing immune responses or developing vaccines. The continued exploration of CD46 and its recombinant forms holds promise for advancing our understanding of immune regulation and addressing various diseases linked to its dysregulation.
