Analytical Data
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Gene name
CD3 epsilon
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简介
The CD3E/CD3 epsilon 1-27 peptide is critical in the TCR-CD3 complex, transmitting signals during T cell activation. When APC activates the TCR, CD3E undergoes LCK/FYN-mediated phosphorylation together with ITAM, initiating downstream signaling. CD3 epsilon 1-27 peptide Protein, Cynomolgus (HEK293, Fc-Avi) is the recombinant cynomolgus-derived CD3E/CD3 epsilon 1-27 peptide protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
- Application
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Alternative Names
CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
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Species
Cynomolgus
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Source
HEK293
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Tag
C-Avi;C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q95LI5
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Expression Region
D22-T48
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Protein Length
Partial
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Molecular Weight
40-50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD3 epsilon is a crucial component of the T-cell receptor (TCR) complex, playing an essential role in T-cell activation and signal transduction. The study of CD3 epsilon is significant due to its involvement in immune responses and potential implications for immunotherapies, particularly in cancer treatment and autoimmune disorders. Research indicates that mutations or alterations in the CD3 epsilon gene can lead to immunodeficiencies, highlighting its importance in maintaining immune system integrity. Additionally, recombinant CD3 epsilon proteins have gained attention for their use in therapeutic applications, such as enhancing T-cell responses against tumors and modulating immune functions. Understanding the structure and function of CD3 epsilon can aid in the development of novel therapeutic strategies that harness the immune system to combat malignancies and improve patient outcomes in immunological diseases. Recent advancements in protein engineering and recombinant DNA technology enable researchers to produce and analyze CD3 epsilon with greater precision, paving the way for innovative approaches in the modulation of T-cell activity and enhancing the efficacy of existing immunotherapies. Overall, the investigation of CD3 epsilon and its recombinant forms holds promise for advancing our understanding of T-cell biology and improving therapeutic interventions for a range of diseases.
