Analytical Data
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基因名
CD3 epsilon
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简介
CD3 epsilon is an important component of the TCR-CD3 complex on T lymphocytes and promotes TCR-mediated signaling. When APC activates the TCR, CD3 epsilon, together with CD3D, CD3G, and CD3Z, transmits signals across the cell membrane through ITAMs. CD3 epsilon 1-27 peptide Protein, Human (Biotinylated, HEK293, hFc-Avi) is the recombinant human-derived CD3 epsilon 1-27 peptide protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
- Application
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别名
CD3e; CD3E; T3E; FLJ18683; TCRE; CD3-epsilon; IMD18
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07766
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表达区间
D23-T48
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蛋白长度
Partial
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分子量
40-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD3 epsilon is a crucial component of the T-cell receptor (TCR) complex, playing an essential role in T-cell activation and signal transduction. The study of CD3 epsilon is significant due to its involvement in immune responses and potential implications for immunotherapies, particularly in cancer treatment and autoimmune disorders. Research indicates that mutations or alterations in the CD3 epsilon gene can lead to immunodeficiencies, highlighting its importance in maintaining immune system integrity. Additionally, recombinant CD3 epsilon proteins have gained attention for their use in therapeutic applications, such as enhancing T-cell responses against tumors and modulating immune functions. Understanding the structure and function of CD3 epsilon can aid in the development of novel therapeutic strategies that harness the immune system to combat malignancies and improve patient outcomes in immunological diseases. Recent advancements in protein engineering and recombinant DNA technology enable researchers to produce and analyze CD3 epsilon with greater precision, paving the way for innovative approaches in the modulation of T-cell activity and enhancing the efficacy of existing immunotherapies. Overall, the investigation of CD3 epsilon and its recombinant forms holds promise for advancing our understanding of T-cell biology and improving therapeutic interventions for a range of diseases.
