Analytical Data
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Gene name
CD147
- Application
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Alternative Names
EMMPRIN; BSG; 5F7; M6; OK; TCSF; Basigin(Ok Blood Group); Collagenase stimulatory factor; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor
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Species
Rat
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Source
HEK293
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P26453
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Expression Region
Ala22~Arg324
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Molecular Weight
44-55kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD147, also known as basigin or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a crucial role in various physiological and pathological processes, including cell proliferation, differentiation, and migration, primarily through its interaction with integrins and other proteins in the extracellular matrix. Research has increasingly focused on CD147 due to its implications in cancer progression, cardiovascular diseases, and inflammatory responses. In particular, CD147 is implicated in promoting tumor progression by enhancing matrix metalloproteinase (MMP) activity, facilitating tumor invasiveness and metastasis. The generation of recombinant CD147 proteins has emerged as a valuable tool for elucidating its functional roles and interactions in these processes. By producing CD147 in a controlled environment, researchers can investigate its structure-function relationships, binding properties, and potential as a therapeutic target. Furthermore, recombinant CD147 can be used in the development of diagnostic assays or targeted drug delivery systems, making it a focal point in both basic and translational research. Understanding CD147's mechanisms may pave the way for novel therapeutic strategies aimed at inhibiting its function in diseases characterized by aberrant cell signaling and extracellular matrix remodeling. Thus, the study of CD147 recombinant proteins not only enhances our comprehension of its biological significance but also contributes to the development of innovative approaches to tackle various diseases.
