Analytical Data
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基因名
CD72
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简介
CD72 Protein plays a key role in orchestrating B-cell proliferation and differentiation, forming homodimers with disulfide linkages and interacting with CD5. It engages in tyrosine phosphorylation interactions with PTPN6/SHP-1, indicating its modulation of cellular responses through phosphorylation-based regulatory mechanisms. This underscores the multifaceted role of CD72 in the dynamic landscape of B-cell function and signaling. FITC-Labeled CD72 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD72 protein, expressed by HEK293 , with Fc labeled tag.
- Application
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别名
CD72; Lyb-2; Lyb2
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种属
Human
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表达系统
HEK293
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标签
Fc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21854
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表达区间
R117-D359
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蛋白长度
Extracellular Domain
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分子量
60-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD72 is a type II transmembrane glycoprotein primarily expressed on the surface of B cells and has been implicated in the modulation of B cell activation and signaling. As a member of the immune system's regulatory network, CD72 interacts with its ligand, CD100, to influence B cell responses, and its dysregulation has been associated with various autoimmune diseases and lymphoproliferative disorders. Research on CD72 recombinant proteins has gained attention due to their potential utility in understanding the molecular mechanisms underlying B cell activation and function. By generating CD72 recombinant proteins, researchers can elucidate the role of CD72 in immune responses, explore its interactions with other proteins, and evaluate its potential as a therapeutic target. Studies using these proteins may also provide insights into the development of monoclonal antibodies or other biological agents aimed at modulating B cell activity in the context of diseases such as systemic lupus erythematosus and multiple sclerosis. Thus, the exploration of CD72 recombinant proteins is crucial for advancing our knowledge of B cell biology and developing innovative strategies for treating immune-related conditions.
