Analytical Data
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Gene name
CD6
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简介
The CD6 protein is a cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses through interaction with ALCAM/CD166. It functions as a costimulatory molecule, promoting T cell activation, proliferation, and contributing to the formation of immune synapses. CD6 Protein, Human (HEK293, Fc) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
T-cell differentiation antigen CD6; T12; TP120; CD6
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30203
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Expression Region
H18-E398
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AA Sequence
MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRE
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Protein Length
Extracellular Domain
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Molecular Weight
67.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
CD6 is a significant receptor primarily expressed on T cells and plays a crucial role in cell activation and immune response modulation. Research on CD6 has gained momentum due to its involvement in various autoimmune diseases and malignancies, making it a potential target for immunotherapy. The protein's structure and function have drawn interest, as understanding its interactions can reveal mechanisms behind T cell regulation and differentiation. CD6's engagement with its primary ligand, activated leukocyte cell adhesion molecule (ALCAM), contributes to the formation of immunological synapses, enhancing T cell responses. Moreover, studies have indicated that manipulating CD6 signaling could provide therapeutic strategies for treating conditions such as multiple sclerosis and cancer. As researchers explore CD6’s molecular pathways, the development of recombinant CD6 proteins has become essential for investigating their functional implications and therapeutic potential. This includes engineering soluble forms of CD6 for use in experimental assays, which can facilitate the evaluation of its role in cell signaling and immune system dynamics. The comprehensive understanding of CD6 and its signaling pathways could lead to novel interventions in immunotherapy, enhancing the efficacy of cancer treatments and improving outcomes in autoimmune disorders. Thus, ongoing research into CD6 recombinant proteins is pivotal for advancing therapeutic approaches in immunology and oncology.
