Analytical Data
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Gene name
KIR2DL1
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简介
KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis. This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interaction's enhancement by ARRB2 underscores KIR2DL1's role in complex signaling networks that modulate NK cell function. KIR2DL1 Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Killer cell immunoglobulin-like receptor 2DL1; NKAT-1; CD158a; KIR2DL1
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43626-1
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Expression Region
H22-H245
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Protein Length
Extracellular Domain
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL1 (Killer Immunoglobulin-like Receptor 2DL1) is a receptor expressed on natural killer (NK) cells and a subset of T cells, playing a critical role in the immune response against tumor cells and virus-infected cells. It interacts specifically with HLA-C molecules, modulating NK cell activity and influencing immune tolerance and response. The understanding of KIR2DL1 and its signaling mechanisms has profound implications in cancer immunotherapy and transplantation, as variations in its expression and function can affect an individual's susceptibility to infections and cancer development. The study of KIR2DL1 recombinant proteins is essential for elucidating the structure-function relationship of this receptor, enabling the development of targeted therapies. Furthermore, recombinant KIR2DL1 proteins are valuable tools in elucidating the molecular interactions between NK cells and their ligands, advancing our understanding of immune regulation. Investigating these proteins can lead to insights into how KIR2DL1 modulates NK cell activation and inhibition, potentially guiding the design of KIR2DL1-targeted strategies in clinical settings for enhancing anti-tumor immunity or tolerating transplanted tissues. As research progresses, a deeper characterization of KIR2DL1 recombinant proteins will contribute to the overall understanding of NK cell biology and pave the way for innovative therapeutic approaches in the context of immunology and oncology.
