Analytical Data
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Gene name
TNFR-1/CD120a
- Application
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Alternative Names
CD120A; P55; TNFRSF1A; TBP1; FPF; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR55; TNFR60; P55-R; P60; Tumor necrosis factor receptor 1; Tumor necrosis factor-binding protein 1
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by reducing SDS-PAGE.
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Uniprot
P25118
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Expression Region
Arg239~Cys433
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tumor necrosis factor receptor 1 (TNFR-1), also known as CD120a, is a critical component of the TNF signaling pathway, playing a pivotal role in mediating various cellular responses, including inflammation, apoptosis, and cell survival. The dysregulation of TNFR-1 signaling is implicated in numerous pathological conditions, including autoimmune diseases, cancer, and infectious diseases. Research into TNFR-1/CD120a recombinant proteins has gained attention due to their potential as therapeutic agents, enabling targeted modulation of TNF signaling. Recombinant TNFR-1 proteins can serve as decoy receptors to bind excess TNF-alpha, neutralizing its effects and preventing downstream pathological effects, particularly in inflammatory disorders. Furthermore, the study of TNFR-1/CD120a has advanced our understanding of the receptor's structure, function, and interaction with ligands, facilitating the design of innovative treatments. The development of these recombinant proteins has also opened avenues for exploring novel drug delivery systems and biopharmaceutical applications. The ongoing research into TNFR-1/CD120a not only aims to elucidate its complex signaling mechanisms but also focuses on harnessing its therapeutic potential to improve patient outcomes in various diseases characterized by aberrant TNF signaling.
