Analytical Data
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基因名
TNF-beta/TNFSF1
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简介
TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. TNF-beta/TNFSF1 Protein, Human (HEK293, His) is the recombinant human-derived TNF-beta/TNFSF1 protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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别名
LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha
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种属
Human
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表达系统
HEK293
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01374
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表达区间
L35-L205
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蛋白长度
Full Length of Mature Protein
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分子量
20-25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNF-beta, also known as Tumor Necrosis Factor Superfamily Member 1 (TNFSF1), is a pivotal cytokine in the immune system that plays a critical role in regulating various cellular processes, including inflammation, immune response, and apoptosis. Initially identified for its ability to induce tumor cell death, TNF-beta has since garnered attention for its multifaceted roles in both adaptive and innate immunity. The study of recombinant TNF-beta has gained significant traction due to its potential therapeutic applications in autoimmune diseases, cancer treatment, and immune modulation. Researchers have focused on elucidating the molecular mechanisms underlying TNF-beta signaling pathways, as well as its interactions with specific receptors, such as TNFR1 and TNFR2. Additionally, recombinant proteins allow for the investigation of TNF-beta's effects on various cell types, including T cells, B cells, and macrophages, providing insights into how it orchestrates immune responses. Furthermore, owing to its dual role in promoting inflammation and inducing apoptosis in certain contexts, TNF-beta presents a complex target for drug development, necessitating a deeper understanding of its biological functions. The exploration of TNF-beta/TNFSF1 recombinant proteins is not only instrumental in elucidating the cytokine's biological activities but also offers a promising avenue for designing innovative therapeutic strategies against a range of diseases characterized by dysregulated immune responses.
