Analytical Data
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Gene name
FGFR-1 alpha (IIIc)
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简介
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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Alternative Names
FGF R1a; FGFR1 alpha
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11362-7
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Expression Region
R22-E374
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Protein Length
Extracellular Domain
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Molecular Weight
65-85 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFR-1 alpha (IIIc) is a member of the fibroblast growth factor receptor (FGFR) family, which plays a crucial role in various biological processes such as cell proliferation, differentiation, and survival. Research into FGFR-1 has gained momentum due to its involvement in several pathological conditions, including cancer, where aberrant signaling pathways contribute to tumor growth and metastasis. The FGFR-1 alpha (IIIc) isoform is particularly interesting because of its unique extracellular domain, which allows for specific interactions with various fibroblast growth factors. This isoform is also implicated in developmental processes and tissue homeostasis, making it a potential target for therapeutic interventions. The development of recombinant FGFR-1 alpha (IIIc) proteins enables detailed studies of its biological functions and interactions. By understanding the structure and activity of this receptor, researchers aim to elucidate its role in normal physiology and disease states, paving the way for the design of novel drugs that can inhibit FGFR signaling in cancers where this pathway is overactive. Furthermore, FGFR inhibitors are being explored as treatment options for various tumors, underscoring the importance of FGFR-1 alpha (IIIc) research in the context of targeted therapies. Overall, the investigation of this specific FGFR isoform holds promise for advancing our understanding of growth factor signaling and developing innovative strategies to combat FGFR-associated diseases.
