Analytical Data
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基因名
CEACAM8/CD66b
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简介
CEACAM8/CD66b protein is a cell surface glycoprotein that promotes calcium-independent heterophil cell adhesion to other carcinoembryonic antigen-related cell adhesion molecules, particularly CEACAM6, in activated neutrophils Especially obvious. CEACAM8/CD66b Protein, Human (His-SUMO) is the recombinant human-derived CEACAM8/CD66b protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31997
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表达区间
Q35-D320
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氨基酸序列
QLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSD
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蛋白长度
Full Length of Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CEACAM8, also known as CD66b, is a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family that plays a crucial role in the immune response, particularly in neutrophil function and inflammation. This glycoprotein is primarily expressed on the surface of neutrophils and has been implicated in neutrophil adhesion, migration, and activation. Its interaction with other immune cells and pathogens has made it a subject of interest in both immunology and oncology. Research has shown that CEACAM8/CD66b can enhance neutrophil responses during infections and contribute to the pathogenesis of various diseases, including autoimmune disorders and cancer. The study of recombinant CEACAM8/CD66b proteins has garnered attention for their potential therapeutic applications, such as in the development of vaccines or as biomarkers for disease progression. Understanding the structural and functional properties of this protein can provide insights into its role in immune signaling and may contribute to novel treatment strategies targeting inflammatory diseases. Advances in recombinant protein technology have allowed for the production and characterization of CEACAM8/CD66b, facilitating investigations into its biological functions and interactions. Consequently, ongoing research in this area aims to elucidate the molecular mechanisms underlying CEACAM8/CD66b's involvement in immune responses and its potential as a therapeutic target in various clinical settings.
