Analytical Data
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Gene name
CDCP1
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简介
CDCP1 is a cell surface glycoprotein that may contribute to autoimmune diseases such as encephalomyelitis, multiple sclerosis, and inflammatory arthritis. CDCP1 mediates anti-adhesion and anti-migration by negatively regulating integrin receptors. CDCP1 promotes tumor proliferation and metastasis by activating MAPK/ERK and AKT signaling pathways. CDCP1 Protein, Rat (HEK293, His) is the recombinant rat-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
CDCP1; CD318; SIMA135; TRASK; UNQ2486; PRO5773
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Species
Rat
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
D3ZVA1
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Expression Region
S29-T666
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Protein Length
Partial
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Molecular Weight
90-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDCP1, or CUB Domain Containing Protein 1, is a transmembrane protein that has garnered significant interest in cancer research due to its overexpression in various malignancies, including breast, colorectal, and lung cancers. It plays a crucial role in cellular processes such as cell adhesion, migration, and invasion, which are all critical in tumor progression and metastasis. The protein’s involvement in cancer makes it a potential biomarker for diagnosis and a target for therapeutic interventions. Research into CDCP1 has revealed its association with oncogenic signaling pathways, thereby influencing tumor microenvironments and cancer cell behavior. Furthermore, the development of recombinant CDCP1 proteins has facilitated studies aimed at understanding its structural properties and functional mechanisms. By utilizing techniques such as monoclonal antibody generation and protein engineering, scientists are probing into CDCP1’s interactions with other cellular molecules, shedding light on its role in tumor biology. As a result, CDCP1 not only serves as a promising candidate for further exploration in cancer treatment but also enhances our understanding of the molecular underpinnings of tumorigenesis and metastatic dissemination.
