Analytical Data
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基因名
IL-12R beta 1
- Application
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别名
CD212; IL12R-B1; IL12-RB1; IL-12R-Beta1; IL12RB
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by reducing SDS-PAGE.
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蛋白编号
Q60837
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表达区间
Ser284~Arg348
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-12R beta 1, a key component of the interleukin-12 receptor complex, plays a crucial role in modulating immune responses, particularly in promoting Th1-type immune responses against intracellular pathogens and tumors. The receptor is predominantly expressed on T and natural killer (NK) cells, and its activation is critical for the proliferation and functional activation of these immune cells. Research into IL-12R beta 1 has gained significant attention due to its potential implications in various diseases, including autoimmune disorders, infectious diseases, and cancers. Understanding the signaling pathways and mechanisms involving IL-12R beta 1 could provide insights for developing novel immunotherapeutic strategies. Recombinant IL-12R beta 1 proteins have been generated for use in functional assays, structural studies, and potential therapeutic applications. These studies aim to delineate the receptor's intricate roles in immune regulation and to harness its properties for enhancing antitumor immunity or modulating inflammatory responses. The development of IL-12R beta 1-based therapies holds promise for improving clinical outcomes in various conditions where the immune system plays a pivotal role.
