Analytical Data
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Gene name
Coagulation factor III/F3
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简介
Tissue Factor Protein plays a critical role in blood coagulation.It binds to coagulation factors, activating clotting cascades.Tissue Factor Protein interacts with cells, promoting thrombosis and inflammation.Understanding its functions can aid in developing treatments for blood disorders and cardiovascular diseases.Tissue Factor Protein, Rat (HEK293, His) is the recombinant rat-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
CD142; Coagulation Factor III; F3; TF; TFA; Tissue Factor
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Species
Rat
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q66HI4
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Expression Region
M1-E252
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AA Sequence
MAIPMRPRLLAALAPTFLGFLLLQVAAGAGTPPGKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKYKCTGTTDTECDLTDEIVKDVNWTYEARVLSVPWRNSTHGKETLFGTHGEEPPFTNARKFLPYRDTKIGQPVIQKYEQDGTKLKVTVKDSFTLVRKNGTFLTLRQVFGNDLGYILTYRKDSSTGRKTNTTHTNEFLIDVEKGVSYCFFVQAVIFSRKTNHKSPESITKCTEQWKSVLGE
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Protein Length
Partial
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Molecular Weight
47-52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Coagulation factor III, also known as tissue factor (TF), plays a crucial role in the extrinsic pathway of the coagulation cascade, initiating blood clotting upon vascular injury. The research surrounding recombinant tissue factor (rTF) has gained significant momentum due to its potential applications in both therapeutic and diagnostic realms. Historically, TF was found to be a key regulator of hemostasis, but its overexpression is also linked to pathological conditions, including thrombosis and cancer metastasis. Consequently, understanding the structure and function of rTF has important implications for designing targeted therapies that can modulate coagulation processes. Advances in recombinant DNA technology have made it possible to produce high-purity rTF, facilitating studies on its biochemical properties and cellular interactions. Furthermore, rTF is being investigated for its utility in enhancing coagulation in patients with bleeding disorders, as well as its role as a pro-coagulant factor in tumor biology. By elucidating the mechanisms underlying TF function and its recombinant forms, researchers aim to unravel novel therapeutic strategies that can balance coagulation and prevent undesired thrombotic events. The ongoing studies on Coagulation factor III/F3 recombinant protein not only contribute to our fundamental understanding of hemostatic processes but also pave the way for innovative treatments that address critical health challenges.
