Analytical Data
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Gene name
Nectin-2/CD112
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简介
Nectin-2/CD112 Protein, functioning as a laminin alpha-5 receptor, displays potential involvement in intracellular signaling, reflecting its similarity to related proteins. Nectin-2/CD112 Protein, Rat (HEK293, His) is the recombinant rat-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Nectin cell adhesion molecule 2; Poliovirus receptor-related 2; Pvrl2
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Species
Rat
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5FVC5
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Expression Region
Q32-G351
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Protein Length
Partial
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Molecular Weight
46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Nectin-2, also known as CD112, is a member of the Nectin family, which comprises immunoglobulin-like cell adhesion molecules. It plays a crucial role in cellular interactions, including cell adhesion and migration, and is involved in various physiological and pathological processes, such as immune response and tumor progression. The expression of Nectin-2 has been observed in multiple types of tumors, where it facilitates immune evasion by interacting with the DNAM-1 receptor on natural killer (NK) cells and T cells, thereby inhibiting their cytotoxic functions. Consequently, Nectin-2 has garnered attention as a potential target for cancer immunotherapy. Researchers are focused on the development of recombinant Nectin-2/CD112 proteins to better understand its biological functions and to create therapeutic strategies that can block its immunosuppressive effects. These recombinant proteins can also be utilized in the study of Nectin-2's role in tumor biology, as well as in the development of Nectin-2-targeted therapies, such as monoclonal antibodies or fusion proteins. By elucidating the mechanisms by which Nectin-2 modulates immune responses, scientists aim to enhance the effectiveness of cancer immunotherapies and improve patient outcomes.
