Analytical Data
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Gene name
ICAM-2/CD102
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简介
The ICAM-2/CD102 protein is a key player in cellular interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It inhibits LFA-1-dependent cell adhesion and contributes to lymphocyte recycling. ICAM-2/CD102 Protein, Mouse (HEK293) is the recombinant mouse-derived ICAM-2/CD102 protein, expressed by HEK293 , with tag free.
- Application
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Alternative Names
Intercellular adhesion molecule 2; ICAM-2; CD102
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Species
Mouse
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Source
HEK293
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Tag
Tag Free
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P35330
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Expression Region
S20-Q222
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AA Sequence
SGEKAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQ
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Protein Length
Partial
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Molecular Weight
38-50 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ICAM-2 (Intercellular Adhesion Molecule 2) is a member of the immunoglobulin superfamily and plays a crucial role in cell adhesion and immune responses. It primarily interacts with the leukocyte integrin CD102 (also known as LFA-1), facilitating the binding of leukocytes to endothelial cells during inflammation. The importance of ICAM-2/CD102 interactions in immune response and inflammatory diseases has driven research into their structure and function. Recombinant proteins of ICAM-2 are valuable tools for studying these interactions in detail. These proteins can be produced in cell culture systems and utilized to investigate the molecular mechanisms underlying cell adhesion, signal transduction, and immune cell trafficking. Additionally, by generating antibodies or inhibitors targeting the ICAM-2/CD102 pathway, researchers aim to explore therapeutic avenues for conditions such as asthma, atherosclerosis, and cancer, where aberrant leukocyte adhesion and migration contribute to disease pathology. Understanding the structure-function relationship of ICAM-2/CD102 through recombinant protein studies not only enhances our comprehension of immune regulation but also paves the way for developing novel immunotherapies and anti-inflammatory strategies. Overall, the study of ICAM-2/CD102 recombinant proteins is pivotal for elucidating the interactions that govern immune responses and for identifying potential clinical applications that could improve patient outcomes in various inflammatory and immunological disorders.
