Analytical Data
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Gene name
FGFR-2 alpha (IIIb)
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21802-3
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Expression Region
R22-E378
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Protein Length
Partial
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Molecular Weight
80-115 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFR-2 alpha (IIIb) is a receptor tyrosine kinase that plays a crucial role in cellular processes such as proliferation, differentiation, and survival. It is part of the fibroblast growth factor receptor (FGFR) family and is predominantly expressed in epithelial tissues, making it significant in developmental biology and tissue maintenance. Aberrant FGFR-2 signaling has been implicated in various pathological conditions, including cancer, particularly in certain types of breast and gastric tumors where mutations or overexpression lead to enhanced tumorigenesis. Research on FGFR-2 alpha (IIIb) recombinant proteins is crucial for understanding its detailed mechanism of action and interactions with fibroblast growth factors (FGFs). Studying this protein aids in elucidating the pathways involved in cell growth and survival, which are often dysregulated in cancer. The development of FGFR-2 alpha (IIIb) recombinant proteins opens avenues for therapeutic interventions, as targeting this receptor could inhibit tumor growth and improve clinical outcomes. Additionally, these recombinant proteins serve as valuable tools for drug discovery, helping to identify potential inhibitors and enhance our understanding of FGFR-related signaling pathways in various diseases. Overall, the exploration of FGFR-2 alpha (IIIb) recombinant proteins is vital for advancing cancer research and developing targeted therapies.
