Analytical Data
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基因名
Fc gamma RIIB/CD32b
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简介
Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and is involved in a variety of effector and regulatory functions. When co-aggregated with BCR, TCR and Fc receptors, it promotes endocytosis of soluble immune complexes (IIB2), modulates antibody production, and downregulates B-cell, T-cell and mast cell activation. Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Low affinity immunoglobulin gamma Fc region receptor II; Fc-gamma-RIIB; Ly-17; CD32; Fcgr2
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08101
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表达区间
T30-P210
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氨基酸序列
THDLPKAVVKLEPPWIQVLKEDTVTLTCEGTHNPGNSSTQWFHNGRSIRSQVQASYTFKATVNDSGEYRCQMEQTRLSDPVDLGVISDWLLLQTPQLVFLEGETITLRCHSWRNKLLNRISFFHNEKSVRYHHYSSNFSIPKANHSHSGDYYCKGSLGRTLHQSKPVTITVQGPKSSRSLP
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蛋白长度
Extracellular Domain
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fc gamma RIIB (CD32b) is an inhibitory receptor for the Fc region of immunoglobulin G (IgG), playing a crucial role in regulating immune responses. It is predominantly expressed on B cells, dendritic cells, and macrophages, where it mediates negative signaling that dampens the activation and proliferation of immune cells. Understanding the role of Fc gamma RIIB is vital for insights into various immune-mediated diseases, including autoimmune disorders, allergies, and cancer. The receptor has emerged as a potential therapeutic target due to its ability to modulate immune responses. Research into recombinant forms of Fc gamma RIIB/CD32b aims to elucidate its structural properties and functional mechanisms, enabling the development of novel therapies that could enhance or inhibit immune responses in a targeted manner. By investigating the interactions between Fc gamma RIIB and its ligands, scientists hope to uncover new strategies to manipulate immune activity for clinical purposes, such as improving vaccine efficacy or preventing tissue damage in autoimmune conditions. The recombinant proteins enable detailed studies of the receptor's signaling pathways and interactions, providing critical knowledge that could lead to innovative immunotherapies and contribute to our understanding of immune regulation.
