Analytical Data
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Gene name
E-Selectin/CD62E
- Application
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Alternative Names
CD62E; CD62-E; E-Selectin; ELAM; ELAM1; ESEL; SEL-E; E-LAM; E-LAM1; E-SEL; LECAM2; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E
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Species
Pig
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P98110
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Expression Region
Trp23~Tyr140
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Molecular Weight
44kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
E-Selectin, also known as CD62E, is a cell adhesion molecule that plays a crucial role in the inflammatory response and leukocyte trafficking. It is primarily expressed on endothelial cells activated by pro-inflammatory cytokines, facilitating the recruitment of leukocytes to sites of inflammation. Research into E-Selectin has gained significant attention due to its involvement in various pathophysiological conditions, including cardiovascular diseases, cancer, and chronic inflammatory disorders. The recombinant form of E-Selectin, generated through modern biotechnological methods, allows for detailed studies of its structure, function, and interactions with ligands such as sialyl Lewisx (sLex) carbohydrate, which is crucial for leukocyte rolling and adhesion. By producing and characterizing E-Selectin recombinant proteins, researchers aim to gain insights into its exact role in immune responses, potential therapeutic applications, and the development of anti-inflammatory strategies. Additionally, the study of E-Selectin can aid in the design of novel drug delivery systems and biomaterials that target inflammatory sites, making it a promising area of research in immunology and therapeutic interventions. Overall, the investigation of E-Selectin/CD62E recombinant proteins represents an important aspect of understanding and manipulating immune cell interactions, with broad implications for treating diseases characterized by dysregulated inflammation.
