Analytical Data
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Gene name
ALCAM/CD166
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简介
ALCAM/CD166 protein is a multifunctional cell adhesion molecule involved in various cell-cell interactions. It promotes T cell activation and immune synapse formation by interacting with CD6. ALCAM/CD166 Protein, Rat (HEK293, Fc) is the recombinant rat-derived ALCAM/CD166 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
CD166 antigen; Activated leukocyte cell adhesion molecule; HB2; KG-CAM; ALCAM
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Species
Rat
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35112
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Expression Region
W28-K527
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Protein Length
Extracellular Domain
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Molecular Weight
94 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166, is an immunoglobulin-like cell adhesion molecule that plays a critical role in various biological processes, including immune response, tissue development, and cancer progression. It is expressed on the surface of various cell types, including leukocytes and epithelial cells, and is involved in the adhesion and migration of immune cells. The study of ALCAM/CD166 has gained significant interest due to its potential implications in disease processes, particularly in tumor biology, where it is often associated with metastasis and poor prognosis. The development of recombinant ALCAM/CD166 protein has enabled researchers to investigate its structural characteristics and functional roles in cell adhesion and signaling mechanisms. By producing this protein in a laboratory setting, scientists can study its interactions with other cellular components, explore its role in immune responses, and assess its potential as a therapeutic target. Furthermore, recombinant ALCAM/CD166 can serve as a valuable tool for the development of diagnostic assays and targeted therapies, particularly in oncology, where manipulating its expression may provide innovative approaches to inhibit tumor progression. The ongoing research into ALCAM/CD166 not only enhances our understanding of its biological significance but also paves the way for novel clinical applications that could improve patient outcomes in diseases such as cancer.
