Analytical Data
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基因名
Integrin alpha V beta 3
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简介
Integrin α V beta 5 proteins, specifically the α-V (ITGAV) subunit, are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences. ITGAV: ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi), has molecular weight of 85-140 kDa.
- Application
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别名
Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3
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种属
Human
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表达系统
HEK293
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标签
C-8*His;C-Avi
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06756-1 (F31-V992)&P05106-1
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表达区间
P06756-1 (F31-V992)&P05106-1 (G27-D718)
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分子量
85-140 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha V beta 3 is a crucial integrin heterodimer that plays a significant role in cell adhesion, migration, and signal transduction processes. This integrin is primarily expressed on activated endothelial cells and various types of cancer cells, making it an important target for cancer therapy and drug delivery systems. Research has demonstrated that alpha V beta 3 is involved in tumor angiogenesis and metastasis, as it mediates the interaction between cells and the extracellular matrix (ECM). The overexpression of this integrin in many tumors highlights its potential as a biomarker for cancer diagnosis and prognosis. Consequently, the development of recombinant alpha V beta 3 proteins has garnered attention in the scientific community, as these proteins can be used to further understand the integrin's biological functions, its role in pathological conditions, and to facilitate drug design. Recombinant integrins can serve as effective tools for evaluating prospective therapeutic agents that target integrin-mediated pathways, providing insights into the mechanisms of tumor progression and enabling the design of integrin-based therapies. Moreover, studying these proteins can help elucidate the molecular interactions that occur during cell adhesion and migration, contributing to advancements in tissue engineering and regenerative medicine. Overall, the research surrounding recombinant integrin alpha V beta 3 underscores its significance in both basic biology and clinical applications, offering numerous avenues for exploration in cancer research and therapeutic development.
