Analytical Data
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Gene name
ERAL1
- Application
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Alternative Names
CEGA; Conserved ERA like GTPase; Conserved ERA-like GTPase; ERA ; Era (E. coli G protein homolog) like 1; Era G protein like 1 (E. coli) ; Era G protein like 1; ERA W; ERA-like protein 1; ERA-W; Eral1; ERAL1_HUMAN; ERAL1A; ERAW
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75616
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Expression Region
1-437aa
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AA Sequence
MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHLPQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLMDIFLCDVDIRLSVKLLK
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Molecular Weight
73.81 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERAL1 is a member of the GTPase superfamily, playing a crucial role in mitochondrial biology and cellular stress responses. Research on ERAL1 has gained attention due to its involvement in mitochondrial translation and ribosome assembly, processes vital for maintaining mitochondrial function and cell metabolism. Dysfunction of mitochondrial protein synthesis is linked to a variety of diseases, including neurodegenerative disorders and cancer. Recent studies have highlighted the critical role ERAL1 plays in the maintenance of mitochondrial homeostasis and the potential consequences of its dysregulation. Additionally, ERAL1 has been implicated in the regulation of cellular responses to stress, with evidence suggesting that it may interact with various signaling pathways. Understanding the mechanisms underlying ERAL1 function and its interactions with other mitochondrial components can provide insights into the etiology of mitochondrial-related diseases and potential therapeutic approaches. The exploration of ERAL1 as a therapeutic target is particularly promising, as enhancing its function may help restore mitochondrial activity in pathological states. Consequently, the study of ERAL1 not only contributes to our understanding of mitochondrial biology but also opens avenues for novel interventions in diseases arising from mitochondrial dysfunction.
