Analytical Data
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基因名
IGF2R
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简介
IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-7*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11717
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表达区间
Q41-E471
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蛋白长度
Partial
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分子量
55-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
The IGF2R (Insulin-like Growth Factor 2 Receptor) is a critical component in cellular signaling, regulation of growth, and metabolism, primarily known for its role in binding insulin-like growth factor 2 (IGF2) and regulating its activity. Dysregulation of IGF2R has been implicated in various pathological conditions, including cancer and growth disorders, making it a key target for therapeutic intervention. Researchers have focused on recombinant IGF2R proteins to understand its structure-function relationship and to develop potential treatments. The production of these recombinant proteins allows for the investigation of the receptor's binding properties, signaling pathways, and interactions with ligands and other molecules. Moreover, these studies contribute to the understanding of diseases where IGF2R is misregulated, ultimately paving the way for targeted therapies. Advances in protein engineering have further enhanced the ability to create modified versions of IGF2R with improved stability and affinity, providing valuable tools for both basic research and clinical applications. Overall, the investigation of IGF2R recombinant proteins plays a pivotal role in elucidating the biological functions of IGF2R and its potential implications in disease management.
