Analytical Data
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基因名
Integrin alpha X beta 2
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简介
Integrin α-X/β-2 is a receptor for fibrinogen that recognizes GPR sequences. It plays a key role in inflammatory responses, particularly in monocyte adhesion and chemotaxis. Integrin alpha X beta 2 Protein, Human (HEK293, Flag, His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein, expressed by HEK293 , with C-His, C-Flag labeled tag.
- Application
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别名
Integrin alpha X beta 2; CD11c; ITGAX; CD18; ITGB2
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种属
Human
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表达系统
HEK293
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标签
C-His;C-Flag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20702 (P20-P1107)&P05107
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表达区间
P20702 (P20-P1107)&P05107 (Q23-N700)
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分子量
95&130 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha X beta 2, a member of the beta 2 integrin family, plays a crucial role in the immune system, particularly in the adhesion and migration of leukocytes. This integrin, also known as Mac-1 or CD11c/CD18, is prominently expressed on the surfaces of various immune cells, including macrophages and neutrophils, and is essential for their functions in immunological responses. The interest in recombinant proteins of integrin alpha X beta 2 has surged due to their potential applications in studying immune cell adhesion mechanisms, developing novel therapies for inflammatory diseases, and creating targeted drug delivery systems. Research efforts aim to elucidate the structural and functional properties of this integrin to understand its role in immune cell trafficking and activation. By producing recombinant forms of integrin alpha X beta 2, scientists can investigate ligand-binding mechanisms, signaling pathways, and the impact of mutations on integrin function, potentially leading to new therapeutic strategies in treating conditions characterized by immune dysfunction or excessive inflammation. The characterization of this integrin also holds promise for enhancing the efficacy of immunotherapies and understanding disease pathogenesis, making it a significant focus in both basic and applied biomedical research.
