Analytical Data
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Gene name
TGM3
- Application
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Alternative Names
TGM3；Protein-glutamine gamma-glutamyltransferase E
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08188
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Expression Region
2-467aa
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AA Sequence
AALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGM3, or transglutaminase 3, is a member of the transglutaminase family of enzymes, which play vital roles in various biological processes, including cell differentiation, apoptosis, and stabilization of the extracellular matrix. Research has highlighted TGM3’s importance in skin biology, particularly in the formation of the epidermal barrier and in skin diseases such as psoriasis and atopic dermatitis. The enzyme catalyzes the formation of covalent bonds between proteins, leading to cross-linking and increased resistance to degradation. Due to its critical role in skin homeostasis, TGM3 has become a target for therapeutic intervention in dermatological conditions. Recent studies have focused on understanding the molecular mechanisms regulating TGM3 expression and activity, as well as exploring its potential as a biomarker for skin disorders. The development of recombinant TGM3 protein has facilitated these studies, enabling researchers to investigate its structural properties, enzymatic function, and interactions with other skin components. By elucidating the role of TGM3 in skin physiology and pathophysiology, researchers aim to pave the way for novel treatments that can enhance skin health and address conditions linked to TGM3 dysregulation.
