Analytical Data
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基因名
TGM3
- Application
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别名
TGM3；Protein-glutamine gamma-glutamyltransferase E
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08188
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表达区间
2-467aa
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氨基酸序列
AALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFA
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGM3, or transglutaminase 3, is a member of the transglutaminase family of enzymes, which play vital roles in various biological processes, including cell differentiation, apoptosis, and stabilization of the extracellular matrix. Research has highlighted TGM3’s importance in skin biology, particularly in the formation of the epidermal barrier and in skin diseases such as psoriasis and atopic dermatitis. The enzyme catalyzes the formation of covalent bonds between proteins, leading to cross-linking and increased resistance to degradation. Due to its critical role in skin homeostasis, TGM3 has become a target for therapeutic intervention in dermatological conditions. Recent studies have focused on understanding the molecular mechanisms regulating TGM3 expression and activity, as well as exploring its potential as a biomarker for skin disorders. The development of recombinant TGM3 protein has facilitated these studies, enabling researchers to investigate its structural properties, enzymatic function, and interactions with other skin components. By elucidating the role of TGM3 in skin physiology and pathophysiology, researchers aim to pave the way for novel treatments that can enhance skin health and address conditions linked to TGM3 dysregulation.
