Analytical Data
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基因名
TNF RI/TNFRSF1A
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简介
TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region with a Fc tag at the C-terminus[1].
- Application
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别名
Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25118
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表达区间
M1-A212
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蛋白长度
Partial
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分子量
55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tumor necrosis factor receptor 1 (TNFRSF1A), also known as TNF receptor type 1 (TNF RI), is a critical component of the TNF superfamily, playing a pivotal role in mediating various biological responses, including inflammation, cell proliferation, and apoptosis. Dysregulation of TNF RI signaling is implicated in several pathological conditions, such as autoimmune diseases, cancer, and chronic inflammatory disorders. Given its significance, recombinant TNFRSF1A proteins have been a focus of research for their potential therapeutic applications. These recombinant proteins can be utilized to better understand the receptor's functional mechanisms, screen for novel drug candidates, and develop targeted therapies aimed at modulating TNF signaling pathways. The study of TNFRSF1A is crucial not only for its role in fundamental biology but also for its therapeutic potential in treating diseases associated with aberrant TNF signaling. Advances in recombinant DNA technology have facilitated the production of these proteins, enabling detailed structural and functional characterization. By exploring the interactions of TNFRSF1A with its ligands and downstream signaling pathways, researchers aim to uncover new insights that could lead to innovative treatments for a variety of diseases, thus underscoring the importance of continued investigation into this vital receptor.
