Analytical Data
-
基因名
CD36
-
简介
CD36 is a multifunctional glycoprotein that binds to proteins such as thrombospondin, fibronectin, collagen, beta-amyloid and oxidized low-density lipoprotein, as well as lipid molecules such as anionic phospholipids and long-chain phospholipids. CD36 regulates angiogenesis, inflammatory responses, fatty acid metabolism, taste, dietary fat processing, and acts as a TLR4:TLR6 heterodimer coreceptor to mediate inflammatory responses, regulate immune responses and bacterial absorption. CD36 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived CD36 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
- Application
-
别名
Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein 4; GPIV; CD36
-
种属
Mouse
-
表达系统
HEK293
-
标签
C-hFc;C-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q08857
-
表达区间
G30-K439
-
氨基酸序列
GDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIK
-
蛋白长度
Extracellular Domain
-
分子量
110-120 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD36 is a multifunctional membrane glycoprotein that plays a critical role in various physiological and pathological processes, including fatty acid metabolism, inflammation, and immunity. It serves as a receptor for several ligands, including oxidized low-density lipoproteins (oxLDL), long-chain fatty acids, and various pathogens. The dysregulation of CD36 has been implicated in a range of diseases such as atherosclerosis, obesity, and diabetes. Given its importance in these conditions, the study of CD36 recombinant proteins has garnered significant interest. Researchers have focused on characterizing the structure and function of CD36, aiming to better understand its ligand-binding mechanisms and signaling pathways. Additionally, recombinant forms of CD36 can be utilized in various experimental models to assess its role in cell adhesion, migration, and inflammatory responses. This research is further enhanced by advances in protein engineering techniques, enabling the generation of CD36 variants with modified properties. Understanding the physiological and pathological roles of CD36 through recombinant protein studies may pave the way for developing targeted therapies for metabolic and cardiovascular diseases, thus highlighting its potential as a therapeutic target in clinical settings. Overall, the exploration of CD36 recombinant proteins is a rapidly evolving field that holds promise for uncovering new insights into health and disease.
