Analytical Data
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Gene name
gp130/IL6ST
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简介
Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family[1]. gp130 inhibits the cell growth and migration[3], decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity[4][5]. gp130/IL6ST Protein, Rhesus Macaque (HEK293, Fc) is a recombinant protein with a Fc label and is produced by HEK293 cells.
- Application
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Alternative Names
Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST
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Species
Rhesus Macaque
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
G7MTS1
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Expression Region
E23-I618
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
gp130, also known as IL6ST (Interleukin-6 signal transducer), is a crucial co-receptor for various cytokines, including interleukin-6 (IL-6), and plays a significant role in the immune response, inflammation, and hematopoiesis. The gp130 signaling pathway is pivotal in mediating cellular responses to IL-6 family cytokines, and dysregulation of this pathway has been implicated in a range of diseases, including autoimmune disorders, cancers, and chronic inflammatory conditions. The study of recombinant gp130/IL6ST proteins is essential for elucidating the mechanisms underlying these pathologies and for the development of potential therapeutic strategies. By generating recombinant forms of gp130, researchers can investigate its structural and functional properties, assess its interactions with other signaling molecules, and evaluate the impact of specific mutations or modifications on its activity. Moreover, gp130's role in promoting cell proliferation and survival makes it an attractive target for drug development. Understanding gp130’s signaling dynamics and its influence on cellular pathways could pave the way for innovations in treating diseases characterized by abnormal cytokine signaling. Overall, the exploration of gp130/IL6ST recombinant proteins is vital for advancing knowledge in immunology and developing targeted therapies to combat cytokine-related diseases.
