Analytical Data
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Gene name
RAB38
- Application
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Alternative Names
Antigen NY MEL 1 ; Melanoma antigen NY MEL 1; Melanoma antigen NY-MEL-1; NY MEL 1; RAB 38; Rab related GTP binding protein; Rab38; RAB38 member RAS oncogene family; RAB38_HUMAN; Ras related protein Rab 38; Ras-related protein Rab-38; rrGTPbp
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P57729
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Expression Region
1-211 aa
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AA Sequence
MQAPHKEHLY KLLVIGDLGV GKTSIIKRYV HQNFSSHYRA TIGVDFALKV LHWDPETVVR LQLWDIAGQE RFGNMTRVYY REAMGAFIVF DVTRPATFEA VAKWKNDLDS KLSLPNGKPV SVVLLANKCD QGKDVLMNNG LKMDQFCKEH GFVGWFETSA KENINIDEAS RCLVKHILAN ECDLMESIEP DVVKPHLTST KVASCSGCAK S
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Molecular Weight
23.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB38 is a member of the RAB family of small GTPases, which play crucial roles in intracellular vesicular transport, secretion, and organelle dynamics. Originally identified for its role in melanosome function within melanocytes, RAB38 has garnered interest due to its involvement in various cellular processes, including membrane trafficking and exocytosis. Studies suggest that RAB38 is instrumental in the regulation of pigment granule biogenesis and might also influence the transport of other organelles. Moreover, recent research has linked RAB38 to various diseases, such as skin disorders and certain forms of cancer, highlighting its potential as a therapeutic target. The study of RAB38 recombinant proteins has become increasingly significant in understanding its structure-function relationship, signaling pathways, and interactions with effector proteins. By employing recombinant DNA technology, researchers aim to produce RAB38 in a controlled environment, facilitating detailed biochemical and biophysical analyses. Understanding the intricacies of RAB38 function not only sheds light on basic cellular mechanisms but may also contribute to the development of novel strategies for treating diseases associated with RAB38 dysfunction. Thus, the exploration of RAB38 recombinant proteins represents a pivotal step in unraveling its biological roles and therapeutic potential.
