Analytical Data
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Gene name
SIVA1
- Application
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Alternative Names
SIVA1；SIVA；Apoptosis regulatory Protein Siva
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15304
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Expression Region
1-175aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SIVA1, or SIVA1 protein, has emerged as a significant focus of research within the realms of immunology and cell biology due to its pivotal role in regulating apoptosis and T cell homeostasis. Initially identified as an apoptosis-inducing factor, SIVA1 is localized predominantly in lymphoid tissues and has been implicated in the modulation of T cell responses during immune activation and self-tolerance. Its interaction with key apoptotic pathways, particularly through binding to the CD27 receptor, highlights its integral function in shaping immune responses. Research has shown that dysregulation of SIVA1 expression may contribute to various pathological conditions, including autoimmune diseases and cancer, making it a potential therapeutic target. Additionally, the recombinant production of SIVA1 protein facilitates detailed studies of its structure-function relationships and biological activities. By employing techniques such as protein engineering and recombinant DNA technology, scientists aim to elucidate its mechanisms of action in T cell regulation and explore its potential as a biomarker or target for immunotherapeutic interventions. Overall, the study of SIVA1 not only enhances our understanding of immune system dynamics but also opens avenues for novel strategies in treating immune-related disorders.
