Analytical Data
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Gene name
TEKT2
- Application
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Alternative Names
TEKT2；Tektin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UIF3
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Expression Region
1-430aa
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AA Sequence
MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE QNLQAKNLPL DVAIECLTLR ESRRDIDVVK DPVEDELHKE VEVIEATKKA LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM ETLEIDRGCL SLNLRSPNIS LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR EATALTIAET NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AERFVPEVDT FTRTTNSTLS PLKSCQLELA
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Molecular Weight
49.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TEKT2, a member of the tektin family of proteins, plays a crucial role in the structural integrity and function of cilia and flagella, which are essential for cellular motility and sensory functions. Research into TEKT2 has gained prominence due to its potential implications in human health, particularly regarding reproductive biology and male fertility. Abnormalities in TEKT2 expression or function have been linked to asthenozoospermia, a condition characterized by reduced sperm motility, which poses challenges for natural conception. Furthermore, TEKT2 is thought to participate in microtubule stabilization and organization within the flagellar structure, highlighting its importance in motile cilia dynamics. Recent advancements in recombinant protein technology have enabled the production of TEKT2 in heterologous systems, facilitating the study of its biochemical properties, interactions with other cytoskeletal components, and the impact of mutations associated with reproductive disorders. Understanding TEKT2's role at the molecular level may provide insights into the mechanisms underlying flagellar assembly and function, with broader implications for the diagnosis and treatment of fertility issues. Given these considerations, ongoing research on TEKT2 as a recombinant protein continues to unveil its biological significance and potential application in reproductive medicine.
