Analytical Data
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Gene name
NLGN4Y
- Application
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Alternative Names
NLGN4Y；KIAA0951；Neuroligin-4. Y-linked
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFZ3
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Expression Region
1-816aa
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AA Sequence
MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLKNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRHPSPQRNTTNDITHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPFMTPNTITMIPNTLMGMQPLHTFKTFSGGQNSTNLPHGHSTTRV
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Molecular Weight
92 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLGN4Y, or Neurexin-like protein 4Y, is a member of the neuroligin family, which plays a crucial role in synaptic functions and neural development. The gene coding for NLGN4Y is located on the Y chromosome and is particularly significant in the study of male-specific neural processes, including social behavior and cognitive functions. Research into NLGN4Y has gained momentum due to its association with neurodevelopmental and psychiatric disorders, such as autism spectrum disorders (ASD), where mutations and disruptions in synaptic proteins have been implicated. Given the rising prevalence of these disorders and the complex genetic underpinnings involved, NLGN4Y presents a compelling target for understanding the molecular mechanisms at play. Recent studies have focused on the functional characteristics of NLGN4Y protein, including its role in mediating excitatory synapse formation and regulation. Investigating the structural properties of NLGN4Y through recombinant protein expression can provide insights into its interaction with other synaptic proteins, potentially revealing its impact on neuronal connectivity and function. Additionally, exploring NLGN4Y's expression patterns in the brain may shed light on its specific contributions to male cognition and behavior, further emphasizing its relevance in neuropsychiatric research. As the field progresses, characterizing the biochemical properties and physiological effects of NLGN4Y will be essential for elucidating its role in both healthy neural function and the etiology of neurodevelopmental disorders, ultimately paving the way for potential therapeutic strategies targeting synaptic dysregulation.
