Analytical Data
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Gene name
CXCR4
- Application
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Alternative Names
FB22 Fusin HM89 LCR1 Leukocyte-derived seven transmembrane domain receptor
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61073
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Expression Region
1-356aa
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Protein Length
Partial
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Molecular Weight
44.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCR4, a chemokine receptor also known as C-X-C chemokine receptor type 4, plays a pivotal role in immune response, cell migration, and various physiological processes. It is primarily recognized for its involvement in HIV entry into host cells, making it a critical target for therapeutic intervention in HIV/AIDS. Recent studies have highlighted the role of CXCR4 in numerous other pathological conditions, including cancer metastasis, where its overexpression is associated with poor prognosis and increased tumor spread. The receptor is involved in several cellular signaling pathways that influence not just immune cell trafficking, but also the behavior of cancer cells and the tumor microenvironment. As a result, the development of CXCR4 recombinant proteins has gained significance for both basic research and clinical applications. These proteins can be utilized as research tools to better understand CXCR4 signaling mechanisms, facilitate drug development, and explore potential therapeutic agents that can block CXCR4 functionality. Additionally, the production of CXCR4 recombinant proteins can aid in the design of specific inhibitors that target this receptor, providing new avenues for treatment in various diseases, including cancer and viral infections. Understanding the structure, function, and interactions of CXCR4 through recombinant technology may reveal crucial insights into disease mechanisms and open doors for novel therapeutic strategies. Overall, the exploration of CXCR4 recombinant proteins represents a promising frontier in biomedical research with potential applications in immunology, oncology, and virology.
