Analytical Data
-
Gene name
gp130
-
简介
Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family[1]. gp130 inhibits the cell growth and migration[3], decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity[4][5]. gp130/IL6ST Protein, Human (HEK293, Fc) is a recombinant protein with a Fc tag produced by HEK293 cells.
- Application
-
Alternative Names
Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST
-
Species
Human
-
Source
HEK293
-
Tag
C-hFc
-
Purity
> 90% as determined by SDS-PAGE.
-
Uniprot
P40189
-
Expression Region
E23-I618
-
AA Sequence
ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEI
-
Protein Length
Extracellular Domain
-
Molecular Weight
97-130 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Related Products
Protein Description
gp130 is a signal transducer that plays a crucial role in the interleukin-6 (IL-6) cytokine family signaling pathways, which are integral to various physiological processes, including immune response, hematopoiesis, and inflammation. Dysregulation of gp130 signaling has been implicated in several pathologies, including autoimmune diseases, cancers, and chronic inflammatory disorders. The study of recombinant gp130 protein enables researchers to investigate its structure-function relationships, examine the dynamics of IL-6 family cytokine signaling, and explore its potential as a therapeutic target. Additionally, gp130's ability to form high-affinity complexes with IL-6 or other cytokines leads to the activation of downstream signaling pathways such as STAT3, which further highlights its importance in cellular signal transduction. Investigations into gp130 functionality can also facilitate the development of novel biomolecular inhibitors that may effectively modulate its activity in disease contexts. Overall, advancing our understanding of gp130 through recombinant protein studies is crucial for the development of new therapeutic strategies aimed at modulating immune and inflammatory responses.
