Analytical Data
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基因名
GPNMB
- Application
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别名
GPNMB;HGFIN;NMB;Transmembrane glycoProtein NMB
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14956
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表达区间
22-474aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSAKRFHDVLGNERPSAYMREHNQLNGWS SDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAV NLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGT GQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNT ANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDR NSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHT VNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLGPAGDNPLE LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLI DFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNG SGTYCVNLTLGDDTSLALTSTLISVP
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分子量
53 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPNMB (glycoprotein non-metastatic B) is a transmembrane glycoprotein that has garnered significant interest in cancer research due to its dual role in tumors and immune regulation. Initially identified as a protein linked to melanoma metastasis, GPNMB is now recognized for its involvement in various tumor types, including breast, lung, and colon cancers. Overexpression of GPNMB in these malignancies is often associated with aggressive tumor behavior and poor prognosis, making it a potential biomarker for metastatic disease. Furthermore, GPNMB plays a crucial role in modulating the immune response, influencing both innate and adaptive immunity. Its expression in immune cells, particularly in macrophages and dendritic cells, suggests that it could serve as a target for immunotherapy. The development of recombinant GPNMB proteins aims to elucidate its functional roles in cancer progression and immune modulation. By studying the structural and biochemical properties of GPNMB, researchers hope to better understand its mechanisms of action and explore its potential as a therapeutic target or diagnostic marker. As a result, GPNMB continues to be a focal point of research aimed at developing new cancer treatments and improving patient outcomes.
