Analytical Data
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基因名
FUT7
- Application
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别名
FUT7;Alpha-(1.3)-fucosyltransferase 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q11130
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表达区间
37-342aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSPRGTPAPQPTITILVWHWPFTDQPPEL PSDTCTRYGIARCHLSANRSLLASADAVVFHHRELQTRRSHLPLAQRPRG QPWVWASMESPSHTHGLSHLRGIFNWVLSYRRDSDIFVPYGRLEPHWGPS PPLPAKSRVAAWVVSNFQERQLRARLYRQLAPHLRVDVFGRANGRPLCAS CLVPTVAQYRFYLSFENSQHRDYITEKFWRNALVAGTVPVVLGPPRATYE AFVPADAFVHVDDFGSARELAAFLTGMNESRYQRFFAWRDRLRVRLFTDW RERFCAICDRYPHLPRSQVYEDLEGWFQA
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FUT7, or fucosyltransferase 7, is an important enzyme involved in the biosynthesis of fucosylated glycans, which play critical roles in various biological processes such as cell adhesion, immune response, and cancer metastasis. Research on FUT7 has gained traction due to its implications in several pathological conditions, including inflammatory diseases and tumor progression. The enzyme catalyzes the transfer of fucose, a sugar, to glycoproteins and glycolipids, influencing molecular interactions and signaling pathways. Abnormal expression of FUT7 has been linked to the enhanced invasiveness of cancer cells, making it a potential biomarker for cancer diagnosis and a target for therapeutic intervention. Studies have explored the structure, function, and regulation of FUT7, as well as its role in modulating the tumor microenvironment. Furthermore, recombinant FUT7 proteins have been utilized in various assays aimed at understanding fucosylation's impact on cellular behaviors. As the understanding of FUT7's functions expands, so does the potential for developing novel strategies to manipulate fucosylation for therapeutic purposes, highlighting the enzyme's relevance in both basic research and clinical applications. Consequently, FUT7 remains a focal point of ongoing studies aimed at uncovering the complexities of glycosylation and its broader implications in health and disease.
