Analytical Data
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基因名
EXOSC8
- Application
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别名
EXOSC8；OIP2；RRP43;Exosome complex component RRP43
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96B26
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表达区间
1-276aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAAGFKTVEPLEYYRRFLKENCRPDGR ELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKG YVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCIS PGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALA EVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMD EEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC8, a core component of the exosome complex, plays a crucial role in RNA metabolism, including degradation and processing of various RNA species. Its function is vital for maintaining cellular homeostasis and regulating gene expression. Mutations in the EXOSC8 gene have been linked to a range of disorders, including neurological diseases and certain syndromes characterized by developmental delays and other abnormalities. Given its significance, researchers have focused on studying the recombinant EXOSC8 protein to better understand its structure and function, as well as its interactions with other proteins within the exosome complex. The production of recombinant EXOSC8 allows for detailed biochemical characterization and functional assays, which can reveal insights into its role in RNA decay pathways and cellular responses to stress. Additionally, elucidating the mechanism by which EXOSC8 contributes to disease could lead to the development of potential therapeutic strategies for conditions associated with its dysfunction. Overall, the study of recombinant EXOSC8 not only enhances our understanding of fundamental cellular processes but also has important implications for medical research and therapeutic development.
